Pharmacology
Mechanism of Action
Carboxymethylcellulose is a cellulose polymer that increases tear viscosity and extends ocular surface contact time. It forms a mucoadhesive layer that supplements the aqueous tear layer, reduces tear film break-up time (TBUT), and protects corneal epithelium from desiccation-induced damage.
47%
Improvement in TBUT score
after 4-week CMC therapy vs baseline
62%
Symptom relief at 2 weeks
OSDI score improvement
> 300M
DED patients worldwide
largest ophthalmic indication globally
pH 6.8–7.8
Formulation pH range
matched to natural tear pH
Approved Indications
Dry eye disease (DED) / keratoconjunctivitis sicca
Contact lens-associated dryness
Post-refractive surgery ocular surface support
Computer vision syndrome (digital eye strain)
Pre- and post-cataract surgery lubrication
Why Manufacture Carboxymethylcellulose with Addams
Single-dose LDPE ampoules for preservative-free compliance
Multi-dose with benzalkonium-free alternative preservative
Hypertonic formulation option for severe DED
Validated sterility per Ph.Eur. and USP requirements