Pharmacology
Mechanism of Action
Diclofenac inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis. This dual inhibition delivers potent analgesic, anti-inflammatory, and antipyretic effects — making it one of the most prescribed injectable NSAIDs globally.
60–80%
Pain reduction within 30 min
vs placebo in post-op studies
2–6 hrs
Duration of analgesic effect
single 75 mg IM dose
99%
Plasma protein binding
highly albumin-bound
1–2 hr
Peak plasma concentration
after IM administration
Approved Indications
Post-operative pain management
Acute musculoskeletal disorders
Renal colic & biliary colic
Cancer pain (adjunct therapy)
Migraine & acute pain episodes
Why Manufacture Diclofenac with Addams
High-purity API sourcing with full CoA documentation
pH-controlled buffer system for enhanced stability
Nitrogen-purged vials to prevent oxidation
Each batch validated against BP/USP monograph