Pharmacology
Mechanism of Action
Lidocaine blocks fast voltage-gated sodium channels in neuronal membranes, preventing depolarisation and action potential propagation. In cardiac tissue, it selectively suppresses automaticity in the His-Purkinje system with minimal effect on normal conduction, making it effective for ventricular arrhythmias.
<5 min
Onset of local anaesthetic action
depending on injection site
1–3 hrs
Duration of nerve block
without epinephrine
65%
Plasma protein bound
to α1-acid glycoprotein
90 min
Elimination half-life
hepatic metabolism (CYP1A2)
Approved Indications
Regional and epidural anaesthesia
Cardiac ventricular arrhythmias
Procedural pain management in ICU
Wound infiltration anaesthesia
Why Manufacture Lidocaine with Addams
Available in 1% and 2% concentrations in separate SKUs
Epinephrine-free formulations for cardiac safety
pH adjusted to 6.0–7.0 for tissue compatibility
Graduated markings on syringe barrel for dose precision